Proton Beam Craniospinal Irradiation Reduces Acute Toxicity for Adults With Medulloblastoma
نویسندگان
چکیده
منابع مشابه
A review of dosimetric and toxicity modeling of proton versus photon craniospinal irradiation for pediatrics medulloblastoma.
BACKGROUND Craniospinal irradiation (CSI) is the standard radiation therapy treatment for medulloblastoma. Conventional CSI photon therapy (Photon-CSI) delivers significant dose to surrounding normal tissue (NT). Research into pediatric CSI with proton therapy (Proton-CSI) has increased, with the aim of exploiting the potential to reduce NT dose and associated post-treatment complications. This...
متن کاملAcute toxicity profile of craniospinal irradiation with intensity-modulated radiation therapy in children with medulloblastoma: A prospective analysis
BACKGROUND To report on the acute toxicity in children with medulloblastoma undergoing intensity-modulated radiation therapy (IMRT) with daily intrafractionally modulated junctions. METHODS Newly diagnosed patients, aged 3-21, with standard-risk (SR) or high-risk (HR) medulloblastoma were eligible. A dose of 23.4 or 36.0 Gy in daily fractions of 1.8 Gy was prescribed to the craniospinal axis,...
متن کاملProton beam therapy for medulloblastoma.
It is heartening to read a report of good functional outcomes following proton beam therapy in young patients with medulloblastoma, including the absence of many unpleasant side eff ects that can occur after conventional photon therapy. The authors quote UK research, which criticises the current proton therapy treatment policy of dividing the x-ray (photon) equivalent dose by 1·1. This is done ...
متن کاملLate toxicity following craniospinal radiation for early-stage medulloblastoma.
BACKGROUND The purpose of this study is to review late toxicity following craniospinal radiation for early-stage medulloblastoma. MATERIAL AND METHODS Between 1963 and 2008, 53 children with stage M0 (n = 50) or M1 (n = 3) medulloblastoma were treated at our institution. The median age at diagnosis was 7.1 years (range 1.2-18.5). The median craniospinal irradiation (CSI) dose was 28.8 Gy (ran...
متن کاملStandardized treatment planning methodology for passively scattered proton craniospinal irradiation
BACKGROUND As the number of proton therapy centers increases, so does the need for studies which compare proton treatments between institutions and with photon therapy. However, results of such studies are highly dependent on target volume definition and treatment planning techniques. Thus, standardized methods of treatment planning are needed, particularly for proton treatment planning, in whi...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2013
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2013.01.014